Advanced Plasma Exchange for Personalized Wellness & Healthy Aging

Discover the evolving science of longevity with Therapeutic Plasma Exchange (TPE), commonly referred to as plasmapheresis, at Chernoff Cosmetic Surgery in Indianapolis.

Through Chernoff Vitality and our affiliation with Lifespan Edge, co-founded by renowned preventive medicine physician Dr. Michael Roizen, we offer patients access to advanced plasma exchange technology as part of our personalized wellness and healthy aging program.

Therapeutic Plasma Exchange is a medical procedure that separates your red blood cells from the plasma in your blood. Your plasma contains the inflammatory and garbage components that can have a negative effect on your health.

While plasma exchange has been used in conventional medicine for decades, researchers have found improvements in biological aging, inflammation, cognitive health, and longevity with this innovative treatment.

At Chernoff Vitality, we combine medical expertise, individualized evaluations, and evolving scientific research to help patients make informed decisions about their wellness.

Look Better. Feel Better. Live Better.

Dr. Chernoff Explains Therapeutic Plasma Exchange

Hear directly from Dr. Gregory Chernoff as he discusses Therapeutic Plasma Exchange, how plasmapheresis works, and why this advanced medical procedure has been incorporated into the Chernoff Vitality program.

Advancing Longevity Medicine With Lifespan Edge

Featuring Dr. Michael Roizen, Co-Founder of Lifespan Edge

Dr. Chernoff is honored to be an affiliate of Lifespan Edge, a longevity-focused organization co-founded by Dr. Michael Roizen and John Mauldin, to offer Therapeutic Plasma Exchange (TPE) in Indianapolis.

Dr. Michael Roizen is a nationally recognized physician, author, and pioneer in preventive medicine and healthy aging. He is the Chief Wellness Officer Emeritus of Cleveland Clinic and is widely known for developing the RealAge concept, which explores how lifestyle and health factors may influence biological aging.

Throughout his career, Dr. Roizen has focused on preventive healthcare, wellness, and understanding the factors that contribute to healthier aging. Through Lifespan Edge, Dr. Roizen and his team are exploring emerging approaches to longevity medicine, including advanced diagnostic testing and Therapeutic Plasma Exchange.

A Science-Focused Approach to Longevity

Lifespan Edge emphasizes several important principles:

Research-Informed Medicine: Incorporating scientific findings and emerging clinical research into longevity-focused care.
Personalized Evaluations: Considering individual health histories, laboratory results, and wellness goals.
Advanced Medical Technology: Exploring innovative procedures such as Therapeutic Plasma Exchange.
Data-Driven Care: Using clinical assessments and biomarkers to inform medical decision-making.
Physician-Guided Treatment: Prioritizing medical oversight, patient education, and individualized treatment recommendations.

Through our relationship with Lifespan Edge, Chernoff Vitality brings this approach to patients interested in plasmapheresis and advanced wellness medicine in Indianapolis.

BUTTON: LEARN MORE ABOUT LIFESPAN EDGE

What Is Plasmapheresis? Understanding Therapeutic Plasma Exchange

Plasmapheresis is a medical process that separates plasma, the liquid portion of blood, from red blood cells, white blood cells, and platelets. Plasma contains water, proteins, antibodies, clotting factors, and signaling molecules that circulate throughout the body.

Although the terms plasmapheresis and Therapeutic Plasma Exchange (TPE) are frequently used interchangeably, there is a technical difference:

Plasmapheresis: The process of separating plasma from the cellular components of blood.
Therapeutic Plasma Exchange (TPE): The removal of a portion of the separated plasma and replacement with an appropriate solution, such as albumin, before returning the remaining blood components to the patient.

Plasmapheresis and plasma exchange procedures have been used in conventional medicine for decades, particularly in the treatment of certain autoimmune, neurological, and blood-related conditions.

Researchers have also investigated how Therapeutic Plasma Exchange influences circulating proteins and biological markers associated with aging.

At Chernoff Vitality, an affiliate of Lifespan Edge, Therapeutic Plasma Exchange is now available.

The Science Behind Therapeutic Plasma Exchange (TPE) and Healthy Aging

Research on Biological Aging, Inflammation, and Cognitive Health

Blood plasma contains thousands of substances involved in communication between cells, immune function, and other biological processes. The composition of plasma changes with age.

Research has shown that circulating plasma components influence measurable biological markers associated with aging and health.

Dr. Chernoff is encouraged by the emerging research examining the potential benefits of Therapeutic Plasma Exchange for healthy aging.

Key Findings From Plasma Exchange Research

Research involving plasma exchange and patients with Alzheimer's disease has reported the following findings:

52% less decline in activities of daily living.
66% less decline in cognitive function.
61% less decline in patients with moderate Alzheimer's disease.
15% improved preservation of hippocampal volume and reduced brain metabolic decline.

These findings have contributed to increased interest in plasmapheresis for longevity and healthy aging. Results depend on the study population, treatment protocol, and outcomes measured, and do not establish that TPE prevents aging or Alzheimer's disease.

Areas of Ongoing Research

1. Biological Aging and Age-Related Biomarkers

Researchers have shown that Therapeutic Plasma Exchange can influence measurable biological markers associated with aging.

2. Cognitive Health and Alzheimer's Disease Research

The AMBAR (Alzheimer Management by Albumin Replacement) study investigated plasma exchange with albumin replacement in patients with mild-to-moderate Alzheimer's disease, reporting encouraging findings in certain measures of cognition and function.

3. Inflammation and Immune Function

Plasma contains antibodies, inflammatory mediators, and proteins involved in immune signaling. Researchers have demonstrated that plasma exchange can alter these circulating substances and influence biological processes associated with inflammation and immune function.

4. Longevity and Preventive Medicine

Longevity medicine focuses on understanding factors that influence lifespan and healthspan.

Healthspan refers to the years a person lives in relatively good health. Scientists are exploring how circulating plasma components may affect age-related biological processes.

Explore the Research Through Lifespan Edge

Lifespan Edge provides educational resources and information about ongoing research related to Therapeutic Plasma Exchange, including:

Plasma exchange and biological aging.
Age-associated biomarkers and circulating proteins.
The AMBAR study and cognitive health.
Plasma exchange and age-related physiological changes.
Emerging applications of Therapeutic Plasma Exchange.

These resources offer additional insight into why researchers are studying plasma exchange beyond its established medical applications.

Explore TPE Research at Lifespan Edge

How Does Therapeutic Plasma Exchange Work?

Therapeutic Plasma Exchange works by removing plasma that contains substances potentially contributing to certain diseases or biological processes.

The procedure uses specialized medical equipment to separate plasma from the cellular components of blood.

During treatment, blood circulates through the plasma exchange system. A portion of the plasma is removed and replaced with an appropriate sterile replacement solution, such as albumin, while the remaining blood components are returned to the body.

TPE can be an important treatment option when clinical evidence supports removing specific disease-related substances.

At Chernoff Vitality, every patient begins with an individualized medical evaluation to determine whether Therapeutic Plasma Exchange may be appropriate.

Your TPE Treatment: Step by Step

1. Personalized Medical Evaluation

Before your appointment, a panel of blood tests is required.

Our medical team reviews your laboratory results, health history, current medications, wellness goals, and other relevant factors to determine whether you may be a candidate for Therapeutic Plasma Exchange.

2. IV Access

IV access is established to allow blood to circulate between your body and the plasma exchange equipment.

3. Plasma Separation

Specialized equipment separates plasma from the cellular components of your blood.

4. Plasma Exchange

A portion of the separated plasma is removed and replaced with a sterile replacement solution selected according to the medical treatment protocol.

5. Blood Is Returned

Your remaining blood components, together with the replacement fluid, are returned to your body.

Throughout treatment, our medical team monitors your condition and prioritizes patient comfort and safety.

Why Are Patients Exploring TPE for Longevity?

As preventive medicine and longevity research continue to advance, more individuals are exploring medical approaches that go beyond traditional wellness care.

Therapeutic Plasma Exchange is being investigated for its potential effects on:

Biological aging and age-associated biomarkers.
Inflammation and inflammatory signaling.
Immune system activity.
Cognitive health and neurological function.
Age-related changes in cellular communication.
Overall healthspan and longevity.

Although TPE has established applications for certain medical conditions, its use specifically for longevity and general wellness remains an emerging area of research.

At Chernoff Vitality, our goal is to provide patients with access to advanced and innovative treatments supported by individualized medical evaluation and physician guidance.

Experience Matters: Therapeutic Plasma Exchange Under the Direction of Dr. Gregory Chernoff

Dr. Gregory Chernoff brings more than 30 years of medical and surgical experience.

A triple board-certified facial plastic and reconstructive surgeon, Dr. Chernoff has dedicated his career to advancing patient care through medical innovation, clinical education, and evolving treatment technologies.

His experience extends beyond aesthetic medicine to include regenerative medicine, cellular therapies, personalized wellness, and emerging technologies.

Through Chernoff Vitality, Dr. Chernoff continues to explore advancements that contribute to a broader understanding of health, wellness, and longevity.

Our nursing team is trained under Dr. Chernoff and follows clinical protocols developed by Dr. Roizen for patient evaluation, treatment monitoring, and follow-up.

By combining Dr. Chernoff's medical experience with our affiliation with Lifespan Edge, we provide individualized guidance to patients considering Therapeutic Plasma Exchange in Indianapolis.

What to Expect During Your Plasmapheresis or TPE Appointment

Your experience begins with a consultation and medical evaluation. Our team reviews your medical history, medications, laboratory results, and wellness goals before determining whether treatment may be appropriate.

A Therapeutic Plasma Exchange session typically takes 2–3 hours, although individual treatment times may vary.

Two IV access points are used, and sedation is generally not required.

During your appointment, you may be able to:

Relax or rest comfortably.
Read a book.
Watch television.
Work on a laptop or personal device.

Our medical team monitors you throughout the procedure.

Your provider will also review preparation instructions, potential risks, what to expect during treatment, and any recommended follow-up care.

Therapeutic Plasma Exchange FAQs

Is Plasmapheresis the Same as Therapeutic Plasma Exchange?

The terms are frequently used interchangeably, but there is a distinction.

Plasmapheresis refers to separating plasma from blood, while Therapeutic Plasma Exchange involves removing plasma and replacing it with an appropriate sterile replacement solution, such as albumin.

Dr. Chernoff offers Therapeutic Plasma Exchange (TPE).

Where Can I Receive TPE in Indianapolis?

Chernoff Cosmetic Surgery offers Therapeutic Plasma Exchange at our office in Indianapolis, Indiana.

We are the first and only plastic surgery practice in Indiana and the United States to offer the Lifespan Edge TPE treatment.

Can TPE Help With Longevity?

Researchers have investigated how Therapeutic Plasma Exchange influences certain circulating proteins and biomarkers associated with biological aging.

A human study from the Buck Institute for Research on Aging explored whether TPE could influence biological age.

In the study, adults over 50 experienced measurable changes in biological age, an estimate derived from molecular markers rather than chronological age.

What the Study Found:

1.32 years: Average reduction in measured biological age among participants receiving TPE.
2.61 years: Average reduction among participants receiving plasma exchange combined with intravenous immunoglobulin (IVIG).
Greater response in some participants: Individuals with certain markers associated with poorer metabolic health experienced larger changes.
Human evidence: The study used multiple epigenetic biological clocks to assess changes in biological age.

These findings are promising but preliminary. Changes in biological age biomarkers do not necessarily demonstrate longer life expectancy or improved long-term health outcomes.

How Long Does a TPE Appointment Take?

A Therapeutic Plasma Exchange session may take 2–3 hours. Exact treatment times vary from patient to patient.

Does TPE Require Sedation?

No. Therapeutic Plasma Exchange generally does not require sedation.

How Many TPE Treatments Will I Need?

The recommended protocol described by our team includes:

First week: Two treatments.
One month later: A third treatment.
One month after the third treatment: A fourth treatment.

Additional treatments depend on the condition being treated, individual response, and physician recommendations.

How Will I Know if I Am a Good Candidate for TPE?

Before treatment, our medical team reviews your health history, medications, laboratory results, and potential contraindications.

Patients with certain inflammatory, immunologic, neurological, or hematologic conditions may be evaluated for TPE when medically indicated.

Patients interested in metabolic optimization, longevity, and wellness may also request an evaluation to discuss the current evidence, potential benefits, and limitations of TPE.

Not every patient is an appropriate candidate, and treatment recommendations are individualized.

Are There Risks Associated With TPE?

Like any medical procedure, TPE carries potential risks and side effects.

These may include changes in blood pressure, allergic reactions, bleeding or bruising at IV sites, electrolyte changes, and other complications.

Your provider will discuss potential risks, benefits, alternatives, and appropriate precautions before treatment.

How Is Lifespan Edge Involved With Chernoff Cosmetic Surgery?

Chernoff Cosmetic Surgery is an affiliate site for Lifespan Edge in offering Therapeutic Plasma Exchange.

Lifespan Edge was co-founded by Dr. Michael Roizen, Chief Wellness Officer Emeritus of Cleveland Clinic, and John Mauldin.

Through this affiliation, Chernoff Vitality provides access to TPE using physician-guided protocols and individualized patient evaluations.

A New Approach to Vitality

Personalized Wellness. Advanced Medicine. Evolving Research.

Your health is personal. Your wellness plan should be too.

Chernoff Vitality brings together Dr. Gregory Chernoff's decades of medical experience, advanced wellness technologies, and evolving longevity research.

Through our relationship with Lifespan Edge, we are pleased to offer Therapeutic Plasma Exchange to patients in Indianapolis who are interested in learning more about plasmapheresis and its emerging applications in longevity medicine.

Look Better. Feel Better. Live Better.